Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions

Conclusions and limitations: Our data show a potential pharmacokinetic interaction, most likely via CYP3A4 between amlodipine and RIS, reflected in significantly different C/Ds for RIS, 9-OH-RIS and AM. Although the interaction did not result in significantly higher plasma levels, changes in C/Ds and their distribution with regard to the median concentrations were observed.

http://jop.sagepub.com/cgi/content/abstract/30/8/803?rss=1

Source: Journal of Psychopharmacology - July 12, 2016 Category: Psychiatry Authors: Paulzen, M., Haen, E., Gründer, G., Lammertz, S. E., Stegmann, B., Schruers, K. R., Walther, S., Schoretsanitis, G. Tags: Original Papers Source Type: research