Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-{gamma} signaling axis

In this study, our results demonstrated that STS treatment can effectively prevent the hypoxia-mediated inhibition of the PKG-PPAR- signaling axis in rat distal pulmonary arterial smooth muscle cells (PASMCs) and distal pulmonary arteries. These effects of STS treatment were blocked by pharmacological inhibition or specific small interfering RNA knockdown of either PKG or PPAR-. Moreover, targeted PPAR- agonist markedly enhanced the beneficial effects of STS. These results comprehensively suggest that STS treatment can prevent hypoxia-mediated increases in intracellular calcium homeostasis and cell proliferation, by targeting and restoring the hypoxia-inhibited PKG-PPAR- signaling pathway in PASMCs.

Source: AJP: Cell Physiology - July 12, 2016 Category: Cytology Authors: Jiang, Q., Lu, W., Yang, K., Hadadi, C., Fu, X., Chen, Y., Yun, X., Zhang, J., Li, M., Xu, L., Tang, H., Yuan, J. X.-J., Wang, J., Sun, D. Tags: CALL FOR PAPERS Source Type: research