Effect of Electronic Cigarette Use on the Urge-to-Cough Sensation

Conclusions:
A single session of e-cig use, approximating nicotine exposure of one tobacco cigarette, induces significant inhibition of the Cu, as well as C5. Previous studies implicate nicotine as the agent responsible for suppression of C5, and we hypothesize a similar role for nicotine in the suppression of the Cu. Given our observation of the effect of a single e-cig exposure, studies of the respiratory physiologic implications of repeated or chronic e-cig use are warranted.

Implications:
This is the first study to demonstrate that a single exposure to an e-cig significantly inhibits the Cu as measured by capsaicin cough challenge testing. These findings add to the growing body of evidence that e-cig vapor is not a physiologically benign substance, and support further investigation of the effects of repeated or chronic use of e-cigs on cough sensitivity and other respiratory parameters.

Source: Nicotine and Tobacco Research - July 11, 2016 Category: Addiction Authors: Dicpinigaitis, P. V., Lee Chang, A., Dicpinigaitis, A. J., Negassa, A. Tags: Original Investigation Source Type: research