Evaluation of HBV resistance to tenofovir in patients with chronic hepatitis B using ZNA probe assay in Kerman, southeast of Iran

Conclusions HBeAg had a correlation with A194T mutation (P = 0.02) and tenofovir resistance was seen in 13 patients. Real-time PCR with zip nucleic acid probes is a rapid method to detect mutations in the polymerase region of HBV with high sensitivity and specifity. This method could be used for mutation detection in nt-194 position of polymerase gene for tenofovir resistance and other mutations in drug resistance researches.
Source: Asian Pacific Journal of Tropical Disease - Category: Tropical Medicine Source Type: research