Adjunctive role of MMP‐9 inhibition along with conventional anti‐tubercular drugs against experimental tuberculous meningitis

This study was designed to evaluate whether specific inhibition of MMP‐9 can be beneficial in management of the disease. MMP‐9 levels were inhibited using SB‐3CT or dexamethasone along with conventional drugs for treatment of tuberculous meningitis. Both SB‐3CT and dexamethasone decreased the elevated levels of MMP‐9 in sera and tissues of the infected mice. However, dexamethasone administration had an inhibitory effect on bacillary clearance, while SB‐3CT potentiated the bacillary clearance, suggesting that MMP‐9, if specifically inhibited, can be beneficial in the management of TBM.
Source: International Journal of Experimental Pathology - Category: Pathology Authors: Tags: Original Article Source Type: research