HIF-1-Dependent IL-6 Activation in Articular Chondrocytes Initiating Synovitis in Femoral Head Ischemic Osteonecrosis

Conclusions: Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells, which were significantly decreased by tocilizumab. Clinical Relevance: This study provides new insight into the inherent relationship between the induction of ischemia and the initiation of hip synovitis following ischemic osteonecrosis and suggests a potential therapeutic target in the treatment of the synovitis.

http://jbjs.org/cgi/content/short/98/13/1122?rss=1

Source: JBJS - July 5, 2016 Category: Orthopaedics Authors: Yamaguchi, R., Kamiya, N., Adapala, N. S., Drissi, H., Kim, H. K. W. Tags: Basic Science, Pediatrics Scientific Articles Source Type: research