Effect of Ultrasound and Heat on Percutaneous Absorption of L‐Ascorbic Acid: human in vitro studies on Franz cell and Petri Dish Systems

ConclusionCombination of ultrasound (329 kHz, 20 mW/cm2) and heat (36°C) significantly enhanced LAA transdermal penetration, when the time of treatment was sufficient (5 min). As petri dish model was designed to simulate acoustic respond of dense human tissue to ultrasound, the difference between Franz cell and petri dish models suggests that the enhancement effect of ultrasound/heat on skin penetration in vivo may be greater than that determined on in vitro Franz cell model.This article is protected by copyright. All rights reserved.
Source: International Journal of Cosmetic Science - Category: Dermatology Authors: Tags: Original Article Source Type: research