Constructing thioether‐tethered cyclic peptides via on‐resin intra‐molecular thiol–ene reaction

Thiol–ene reactions have been used in a variety of applications that mostly involve an inter‐molecular pathway. Herein, we report a facile method to construct thioether‐tethered cyclic peptides via an intra‐molecular thiol–ene reaction. This reaction is efficient, selective, and has good residue compatibility. Short peptides with thioether tethers were constructed and were used to construct longer cyclic peptides. This synthetic method may be useful for constructing bioactive peptides. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.

Herein, we report a facile method to construct thioether‐tethered cyclic peptides via intra‐molecular thiol–ene reaction. This reaction is highly efficient and selective with satisfying residue compatibility.

Source: Journal of Peptide Science - June 30, 2016 Category: Biochemistry Authors: Bingchuan Zhao, Qingzhou Zhang, Zigang Li Tags: Research Article Source Type: research