Chronotype and circadian rhythm in bipolar disorder: a systematic review

Despite a complex relationship between mood, sleep and rhythm, the impact of circadian disruptions on bipolar disorder (BD) has not been clarified. The purpose of this systematic review was to define current evidence regarding chronotype and circadian rhythm patterns in BD patients. Forty-two studies were included, involving 3,432 BD patients. Disruption of the biological rhythm was identified, even in drug-naïve BD patients and independently of mood status. Daily profiles of melatonin levels and cortisol indicated a delayed phase.

http://www.smrv-journal.com/article/S1087-0792(16)30059-4/abstract?rss=yes

Source: Sleep Medicine Reviews - June 30, 2016 Category: Sleep Medicine Authors: Matias Carvalho Aguiar Melo, Rafael Leônidas Cristino Abreu, Vicente Bezerra Linhares Neto, Pedro Felipe Carvalhedo de Bruin, Veralice Meireles Sales de Bruin Tags: Clinical Review Source Type: research