Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice

In conclusion, liver-derived IGF-I regulates cortical bone mass, cortical porosity, and mechanical strength under normal (nonloaded) conditions. However, despite an ~70% reduction in circulating IGF-I, the osteogenic response to mechanical loading was not attenuated in the LI-IGF-I–/– mice.

Source: AJP: Endocrinology and Metabolism - June 30, 2016 Category: Endocrinology Authors: Svensson, J., Windahl, S. H., Saxon, L., Sjögren, K., Koskela, A., Tuukkanen, J., Ohlsson, C. Tags: Articles Source Type: research