p53 loses grip on PIK3CA expression leading to enhanced cell survival during platinum resistance

Tumor suppressor p53, a master transcriptional regulator determines cell fate through preferential activation/repression of a myriad of genes during stress. Till date, activation and preferential binding of p53 on different promoters was reported to be influenced by the nature, strength and duration of stress which mediates its post translational modifications. Cisplatin, a widely used cytotoxic drug represses PIK3CA promoter activity and attenuates PI3K/AKT cell survival pathway through p53 activation in sensitive cells.
Source: Molecular Oncology - Category: Cancer & Oncology Authors: Source Type: research