Therapeutic Effect of Intra‐Articular Injection of Ribbon‐Type Decoy Oligonucleotides for Hypoxia Inducible Factor‐1 on Joint Contracture in an Immobilized Knee Animal Model

ConclusionsThe present study demonstrates the important role of HIF‐1 in the initial progression of immobilization‐induced joint contracture, and indicates the possibility of molecular treatment to prevent progression of joint contracture prior to intervention with physical therapy.

Source: The Journal of Gene Medicine - March 31, 2016 Category: Genetics & Stem Cells Authors: Daisuke Sotobayashi, Hirohisa Kawahata, Natsuki Anada, Toshio Ogihara, Ryuichi Morishita, Motokuni Aoki Tags: Research Article Source Type: research