New MAPS for misfolded proteins

Nature Cell Biology 18, 724 (2016).
doi:10.1038/ncb3381

Authors: Norbert Volkmar, Emma Fenech & John C. Christianson
Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now, a parallel clearance system is described that uses the deubiquitylase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-associated protein secretion (MAPS) has important implications for protein quality control and prion-like transmission.

Source: Nature Cell Biology - June 27, 2016 Category: Cytology Authors: Norbert VolkmarEmma FenechJohn C. Christianson Tags: News and Views Source Type: research