p21 shapes cancer evolution

Nature Cell Biology 18, 722 (2016). doi:10.1038/ncb3382 Authors: Vasily S. Romanov & K. Lenhard Rudolph Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A — the gene encoding p21 (also known as WAF1 or CIP1) — is rare in human cancers. Now, a study reports a previously unappreciated oncogenic effect of p21 overexpression that shapes cancer genome evolution through induction of replication stress.

http://feeds.nature.com/~r/ncb/rss/current/~3/J0Fnge2rqQM/ncb3382

Source: Nature Cell Biology - June 27, 2016 Category: Cytology Authors: Vasily S. RomanovK. Lenhard Rudolph Tags: News and Views Source Type: research