Rewiring macrophages for anti-tumour immunity

Nature Cell Biology 18, 718 (2016). doi:10.1038/ncb3384 Authors: Yunqin Lee & Subhra K. Biswas Tumour-associated macrophages facilitate cancer progression, but whether they can be reprogrammed to elicit an anti-tumour response remains unclear. Deletion of the microRNA-processing enzyme Dicer is now shown to rewire macrophages to an anti-tumour mode, leading to an enhanced response to immunotherapy and inhibition of tumour progression.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research