16SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism

It is well established that lncRNAs are aberrantly expressed in cancer where they have been shown to act as oncogenes or tumor suppressors. RNA profiling of 314 colorectal adenomas/adenocarcinomas and 292 adjacent normal colon mucosa samples using RNA-sequencing demonstrated that the snoRNA host gene 16 (SNHG16) is significantly up-regulated in adenomas and all stages of CRC. SNHG16 expression was positively correlated to the expression of Wnt-regulated transcription factors, including ASCL2, ETS2, and c-Myc.

Source: Molecular Oncology - June 25, 2016 Category: Cancer & Oncology Authors: Lise Lotte Christensen, Kirsten True, Mark P. Hamilton, Morten M. Nielsen, Nkerorema D. Damas, Christian K. Damgaard, Halit Ongen, Emmanouil Dermitzakis, Jesper B. Bramsen, Jakob S. Pedersen, Anders H. Lund, Søren Vang, Katrine Stribolt, Mogens R. Madsen Source Type: research