The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target

Nature Reviews Cancer 16, 463 (2016). doi:10.1038/nrc.2016.49 Authors: Xiao Zhen Zhou & Kun Ping Lu Targeted drugs have changed cancer treatment but are often ineffective in the long term against solid tumours, largely because of the activation of heterogeneous oncogenic pathways. A central common signalling mechanism in many of these pathways is proline-directed phosphorylation, which is regulated by many kinases
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research