RNA splicing factors as oncoproteins and tumour suppressors

Nature Reviews Cancer 16, 413 (2016). doi:10.1038/nrc.2016.51 Authors: Heidi Dvinge, Eunhee Kim, Omar Abdel-Wahab & Robert K. Bradley The recent genomic characterization of cancers has revealed recurrent somatic point mutations and copy number changes affecting genes encoding RNA splicing factors. Initial studies of these 'spliceosomal mutations' suggest that the proteins bearing these mutations exhibit altered splice site and/or exon recognition preferences relative to

http://feeds.nature.com/~r/nrc/rss/current/~3/t5lZn6u6z94/nrc.2016.51

Source: Nature Reviews Cancer - June 9, 2016 Category: Cancer & Oncology Authors: Heidi DvingeEunhee KimOmar Abdel-WahabRobert K. Bradley Tags: Review Source Type: research

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