Epigenetics: Histone mutations reprogramme chondroblastoma

Nature Reviews Cancer 16, 411 (2016). doi:10.1038/nrc.2016.70 Author: Sarah Seton-Rogers Lysine-to-methionine mutations in histone H3.3 at position 36 (H3.3K36M) occur in >90% of chondroblastomas. Fang et al. found that the global reduction in H3K36 methylation observed in chondrocytes and chondroblastoma cells with H3.3K36M results from inhibition of the methyltransferases MMSET and NSD2 and SET
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research