Pancreatic cancer: Connecting obesity and cancer mechanistically

Nature Reviews Cancer 16, 411 (2016). doi:10.1038/nrc.2016.69 Author: Sarah Seton-Rogers How obesity worsens outcomes in pancreatic ductal adenoocarcinoma (PDAC) is not clear. Incio et al. showed that obesity promoted desmoplasia, increased tumour growth and impaired delivery of chemotherapy in mouse models of PDAC; these phenotypes were reversed by inhibition of angiotensin II receptor type
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research