Metastasis: CXCR2-targeted therapy for pancreatic cancer

Nature Reviews Cancer 16, 411 (2016). doi:10.1038/nrc.2016.67 Author: Anna Dart Steele et al. found that C-X-C chemokine receptor type 2 (CXCR2) expression in neutrophils and myeloid-derived suppressor cells (MDSCs) at tumour borders correlates with poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Genetic ablation and inhibition of CXCR2 in PDAC mouse models reduced metastasis but

http://feeds.nature.com/~r/nrc/rss/current/~3/YInhAhaCrNY/nrc.2016.67

Source: Nature Reviews Cancer - June 23, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research