Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models

Conclusions In summary, the pharmacological activation of HIFs by 3,4-DHB administration, although it showed renoprotective effects in sepsis-related kidney injury, induced more severe problems in other organs such as the liver during sepsis, leading to increased mortality.
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: BASIC SCIENCE Source Type: research