Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models
Conclusions
In summary, the pharmacological activation of HIFs by 3,4-DHB administration, although it showed renoprotective effects in sepsis-related kidney injury, induced more severe problems in other organs such as the liver during sepsis, leading to increased mortality.
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Schindler, K., Bondeva, T., Schindler, C., Claus, R. A., Franke, S., Wolf, G. Tags: BASIC SCIENCE Source Type: research
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