Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease

Conclusions
Our results indicate a strong association between LVH and enhanced expression levels of FGF23, FGFR4 and calcineurin, activation of NFAT and reduced levels of soluble Klotho in the myocardium of patients with CKD. These alterations are not observed in kidney transplant patients.

Source: Nephrology Dialysis Transplantation - June 21, 2016 Category: Urology & Nephrology Authors: Leifheit-Nestler, M., grosse Siemer, R., Flasbart, K., Richter, B., Kirchhoff, F., Ziegler, W. H., Klintschar, M., Becker, J. U., Erbersdobler, A., Aufricht, C., Seeman, T., Fischer, D.-C., Faul, C., Haffner, D. Tags: BASIC SCIENCE Source Type: research