Addition of Aspirin to a Fish Oil Rich Diet Decreases Inflammation and Atherosclerosis in ApoE-Null Mice

Aspirin (ASA) is known to alter the production of potent inflammatory lipid mediators, but whether it interacts with omega-3 fatty acids (FA) from fish oil to affect atherosclerosis has not been determined. The goal was to investigate the impact of a fish oil enriched diet alone and in combination with ASA on the production of lipid mediators and atherosclerosis. ApoE−/− female mice were fed for 13weeks one of the four following diets: Omega-3 FA deficient (OD), Omega-3 FA Rich (OR) (1.8g Omega-3 FAs/kg · diet per day), Omega-3 FA Rich plus ASA (ORA) (0.1g ASA/kg · diet per day), or an Omega-3 FA deficient plus ASA (ODA) with supplement levels equivalent to human doses.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research