Lactobacillus salivarius reverse diabetes-induced intestinal defense impairment in mice through non-defensin protein

Altered intestinal microbiota and subsequent endotoxemia play pathogenic roles in diabetes. We aimed to study the mechanisms of intestinal defense impairment in type 1 diabetes and the effects of Lactobacillus salivarius as well as fructooligosaccharides (FOS) supplementation on diabetes-induced bacterial translocation. Alterations in the enteric microbiome, expression of mucosal antibacterial proteins, and bacteria-killing activity of the intestinal mucosa in streptozotocin (STZ)-induced diabetic mice and Ins2Akita mice were investigated.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research