Manipulation of Regulatory Cells’ Responses to Treatments for Chronic Hepatitis B Virus Infection

Conclusions: The inhibition of Tregs is a novel therapeutic approach to cure chronically HBV infected patients. However, further studies are needed to investigate the safety and efficacy of this approach.,Objectives: In this study, we focused on treating CHB infection via the manipulation of T cells’ responses to identify possible approaches to cure CHB.,Materials and Methods: All studies relevant to the role of cellular and humoral responses in HBV infection (especially regulatory cells) were investigated via a systematic search of different databases, including PubMed, Scopus, and Google Scholar. Considering extracted data and also our unpublished data regarding the association between regulatory cytokines and CHB, we introduced a novel approach for the induction of seroclearance.,Background: Identification of effective treatments in hepatitis B virus (HBV) infection remains a controversial topic. Although the currently approved drugs for HBV control the disease’s progression and also limit associated outcomes, these drugs may not fully eradicate HBV infection. In addition to better managing patients with chronic hepatitis B (CHB) infection, the induction of seroclearance by these drugs has been a commonly discussed topic in recent years.
Source: Hepatitis Monthly - Category: Infectious Diseases Source Type: research