Elucidating the Mechanism of Tofacitinib Oxidative Decyanation

Conclusion: The proposed mechanism involved the initial oxidation by P450 at the α-carbon to the nitrile group generating an unstable cyanohydrin intermediate; followed by the loss of the nitrile group to form a new geminal diol metabolite (MX).
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research