Ipilimumab-induced colitis: experience from a tertiary referral center
Conclusions:
The rate of diarrhoea related to ipilimumab in real-world practice is substantial, but below the range observed in data from RCTs. Grade 1 colitis can usually be managed symptomatically, without recourse to stopping ipilimumab. When diarrhoea was grade 2 or above, results from glucocorticosteroids use proved disappointing; but infliximab has been shown to work well. Further research is required into the earlier use of infliximab as an effective treatment for ipilimumab-induced diarrhoea.
Source: Therapeutic Advances in Gastroenterology - Category: Gastroenterology Authors: OConnor, A., Marples, M., Mulatero, C., Hamlin, J., Ford, A. C. Tags: Original Research Source Type: research
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