Nicotine Enhances High-Fat Diet-Induced Oxidative Stress in the Kidney

Conclusions: Tobacco smoking or the increasingly popular E-cigarettes—via NIC exposure—could worsen obesity-associated lipotoxicity in the kidney. Hence, our findings could help to develop strategies that mitigate adverse effects of NIC on the obese kidney. Implications: Life expectancy of an obese smoker is 13 years less than a normal weight smoker, which could be linked to the increased renal risk imposed by smoking. NIC—the main component of tobacco smoke, E-cigarettes and replacement therapies—links smoking to renal injury via oxidative stress, which could superimpose renal oxidative stress caused by obesity. Our results substantiate this scenario using a mouse model of diet induced obesity and NIC exposure and imply the augmented long-term renal risk in obese smokers. Also, our study may help to develop strategies that mitigate adverse effects of NIC on the obese kidney.
Source: Nicotine and Tobacco Research - Category: Addiction Authors: Tags: Original Investigation Source Type: research