Clinical mutational profiling of bone metastases of lung and colon carcinoma and malignant melanoma using next‐generation sequencing

CONCLUSIONSNext‐generation sequencing assays demonstrated clinical utility in metastatic bone specimens. FNA (smear and cell block) and core‐biopsy specimens provided adequate resources of nucleic acids for molecular profiling of metastatic bone lesions. The current findings suggest the need for developing specific tissue procurement and processing protocols for bone metastases and greater use of small biopsy and FNA specimens. Cancer Cytopathol 2016. © 2016 American Cancer Society.

Source: Cancer Cytopathology - April 30, 2016 Category: Pathology Authors: Gang Zheng, Ming‐Tseh Lin, Parvez M. Lokhandwala, Katie Beierl, George J. Netto, Christopher D. Gocke, James R. Eshleman, Edward McCarthy, Peter B. Illei Tags: Original Article Source Type: research