Genomic and transcriptomic profiles and in vitro resistance to mitoxantrone and idarubicin in pediatric acute leukemias

ConclusionsIn AML resistance of blasts to idarubicin and mitoxantrone may reflect impaired integrins pathway. In ALL development of resistance is caused by inhibition of B and T cells activation.

Source: The Journal of Gene Medicine - March 31, 2016 Category: Genetics & Stem Cells Authors: Joanna Laskowska, Joanna Lewandowska‐Bieniek, Joanna Szczepanek, Jan Styczyński, Andrzej Tretyn Tags: Research Article Source Type: research