Papain-catalyzed aldol reaction for the synthesis of trifluoromethyl carbinol derivatives

Publication date: Available online 3 June 2016 Source:Journal of Molecular Catalysis B: Enzymatic Author(s): Jun-Tao Guo, Yang Xiang, Zhi Guan, Yan-Hong He Papain from Carica papaya demonstrated catalytic promiscuity was first discovered to catalyze the synthesis of trifluoromethyl carbinol derivatives via aldol reaction between α,α,α-trifluoromethyl ketones and aliphatic ketones in a mixed solvent of DMF and water. The best results of the corresponding aldol products with up to 99% yield and 30% ee were achieved. Graphical abstract

Source: Journal of Molecular Catalysis B: Enzymatic - June 6, 2016 Category: Biochemistry Source Type: research