Early initiation of gonadotropin-releasing hormone antagonist versus long agonist protocols in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection cycles

Purpose: The aim of this study was to compare the efficacy and safety of early initiation of gonadotropin-releasing hormone (GnRH) antagonist and long GnRH agonist protocol in oral contraceptive-pretreated polycystic ovary syndrome (PCOS) patients undergoing intracytoplasmic sperm injection (ICSI) cycles. Design: The study design was a randomized controlled one. Setting: The study was conducted in the tertiary university fertility care unit Materials and methods: Seventy infertile PCOS patients under the age of 35 years coming for the first ICSI trial from January 2012 to December 2014 were randomly allocated to an ovarian stimulation protocol consisting of either GnRH agonist long protocol (control group A) or early initiation of GnRH antagonist (study group B) after pretreatment with oral contraceptive pill. Ovulation was triggered with human chorionic gonadotropin when at least three mature follicles measuring 17 mm were detected. Main outcome measures: The primary outcome included number of gonadotrophin ampoules used per each cycle, days of stimulation, number and degree of maturity of retrieved oocytes, rate of fertilization, and available embryo for transfer. The secondary outcome measures were implantation rate and incidence of ovarian hyperstimulation syndrome (OHSS). Results: Both days of stimulation and number of ampoules of human menopausal gonadotropin were statistically significantly greater in group A than in group B (11.25±1.69 vs. 9.48±0.83, P
Source: Journal of Evidence-Based Women’s Health Journal Society - Category: OBGYN Tags: Original articles Source Type: research