A Novel Approach to Predict Core Residues on Cancer-Related DNA-Binding Domains

In this study, we propose a computational method to predict and locate core residues on DNA-binding domains. In particular, we have selected the cancer-related DNA-binding domains for in-depth studies, namely, winged Helix Turn Helix family, homeodomain family, and basic Helix-Loop-Helix family. The results demonstrate that the proposed method can predict the core residues involved in protein–DNA interactions, as verified by the existing structural data. Given its good performance, various aspects of the method are discussed and explored: for instance, different uses of prediction algorithm, different protein domains, and hotspot threshold setting.

Source: Cancer Informatics - June 1, 2016 Category: Cancer & Oncology Authors: Ka-Chun Wong Source Type: research