Diagnosis and endoscopic management of primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a complex, chronic and progressive fibro-inflammatory destructive cholestatic biliary disease. The exact etiology and pathogenesis are unknown and possibly related to an enhanced immune-mediated response and reaction in the biliary system. PSC is closely associated with inflammatory bowel disease (IBD) and specifically, ulcerative colitis (UC). It is characterized by intrahepatic and/or extrahepatic bile duct stricturing and dilation. Clinical manifestations include abnormal liver tests, jaundice, pruritus and fatigue.
Source: Techniques in Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: SI: Imaging in IBD Source Type: research