Importance of the alternative NF-{kappa}B activation pathway in inflammation-associated gastrointestinal carcinogenesis

Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-B signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-B signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-B signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development.

Source: AJP: Gastrointestinal and Liver Physiology - May 31, 2016 Category: Gastroenterology Authors: Merga, Y. J., O'Hara, A., Burkitt, M. D., Duckworth, C. A., Probert, C. S., Campbell, B. J., Pritchard, D. M. Tags: REVIEWS Source Type: research