A Novel Silk Fiber-Based Scaffold for Regeneration of the Anterior Cruciate Ligament: Histological Results From a Study in Sheep

Conclusion:
The novel silk fiber–based scaffold was able to stimulate ACL regeneration under in vivo conditions. Additional cell seeding led to increased tissue regeneration and decreased silk fiber content at 6 months, whereas these differences were not present at 12 months.

Clinical Relevance:
ACL regeneration using a silk fiber–based scaffold with and without additional cell seeding may provide a new treatment option after joint injuries.

Source: The American Journal of Sports Medicine - May 31, 2016 Category: Sports Medicine Authors: Teuschl, A., Heimel, P., Nürnberger, S., van Griensven, M., Redl, H., Nau, T. Tags: Biology of ligament, Tissue engineering, Stem cell therapy, Knee ligaments, ACL Source Type: research