Effect of silibinin and vitamin E on the ASK1-p38 MAPK pathway in D-galactosamine/lipopolysaccharide induced hepatotoxicity

In conclusion, silibinin and vitamin E decreased ASK1-p38 MAPK pathway through deactivating the upstream signalling ASK1 molecule via increasing the levels of Trx1 and TrxR1 as well as the PP5 to alleviate in D-GalN/LPS induced hepatotoxicity.

Source: Experimental Biology and Medicine - May 31, 2016 Category: Research Authors: Hashem, R. M., Hassanin, K. M., Rashed, L. A., Mahmoud, M. O., Hassan, M. G. Tags: Pharmacology/Toxicology Source Type: research