A Validated Preclinical Animal Model for Primary Bone Tumor Research

Conclusions:
We report an in vivo model that contains human bone matrix and marrow components in one organ. BMP-7 made it possible to maintain viable mesenchymal and hematopoietic stem cells and created a bone microenvironment mimicking human physiology.

Clinical Relevance:
This novel platform enables preclinical research on primary bone tumors in order to test new treatment options.

Source: JBJS - May 31, 2016 Category: Orthopaedics Authors: Wagner, F., Holzapfel, B. M., Thibaudeau, L., Straub, M., Ling, M.-T., Grifka, J., Loessner, D., Levesque, J.-P., Hutmacher, D. W. Tags: Basic Science, Oncology Scientific Articles Source Type: research