Impact of Astroglial Connexins on Modafinil Pharmacological Properties

Conclusions:Our study indicates that flecainide impacts the pharmacological effects of modafinil, likely through the normalization of Cx30-dependent gap junctional coupling in astroglial networks. The enhancement of the wake-promoting, behavioral, and cognitive outcomes of modafinil demonstrated here with flecainide would open new perspectives in the management of sleep disorders such as narcolepsy.Commentary:A commentary on this article appears in this issue on page 1175.Citation:Duchêne A, Perier M, Zhao Y, Liu X, Thomasson J, Chauveau F, Piérard C, Lagarde D, Picoli C, Jeanson T, Mouthon F, Dauvilliers Y, Giaume C, Lin JS, Charvériat M. Impact of astroglial connexins on modafinil pharmacological properties. SLEEP 2016;39(6):1283–1292.
Source: Sleep - Category: Sleep Medicine Source Type: research