Antinociceptive Effect of Racemic Flurbiprofen and Caffeine Co‐Administration in an Arthritic Gout‐Type Pain in Rats

The objective of this work was to evaluate the combination of rac‐Flur + caffeine oral in arthritic gout‐type pain in rats. The antinociceptive effects of the rac‐Flur alone and in combination with caffeine were analyzed on a pain‐induced functional impairment model in rat. rac‐Flur induced a dose‐dependent antinociceptive effect and caffeine did not present any effect. The combination of rac‐Flur and caffeine achieve a higher percentage of antinociceptive effect compared with the individual administration of rac‐Flur. The dose‐response curve (DRCs) shows that the combination of rac‐Flur (31.6 mg/kg) + caffeine (17.8 mg/kg) exhibited the maximal antinociceptive efficacy (294.0 ± 21.2 area units), while rac‐Flur alone (31.6 mg/kg) showed 207.2 ± 35.2 au, thus indicating an increase in efficacy (potentiation). Furthermore, the DRCs of the combinations presented a displacement to the left, indicating a change in the potency. Caffeine is able to increase the effect of rac‐Flur in the arthritic gout‐type pain in rats. Drug Dev Res, 2016.   © 2016 Wiley Periodicals, Inc.
Source: Drug Development Research - Category: Drugs & Pharmacology Authors: Tags: Research Article Source Type: research