Dynamic fluorescent imaging with indocyanine green for monitoring the therapeutic effects of photoimmunotherapy

In conclusion, ICG may serve as a potential indicator of acute cytotoxic effects of mAb‐IR700‐induced PIT even before morphological changes can be seen in targeted tumors. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
A new type of monoclonal antibody (mAb)‐based, highly specific phototherapy (photoimmunotherapy; PIT), which uses a near infrared phthalocyanine dye conjugated with a mAb, leads to immediate, target‐selective necrotic cell death. However, tumor shrinkage takes several days to occur, making it difficult to detect earlier changes in the tumor. Dynamic fluorescence imaging with FDA‐approved indocyanine green can serve as a potential indicator of acute cytotoxic effects of mAb‐IR700‐induced PIT even before morphological changes can be seen in targeted tumors.

Source: Contrast Media and Molecular Imaging - March 19, 2014 Category: Radiology Authors: Towhid Ali, Takahito Nakajima, Kohei Sano, Kazuhide Sato, Peter L. Choyke, Hisataka Kobayashi Tags: Full Paper Source Type: research