Pan‐cancer analysis of copy number changes in programmed death‐ligand 1 (PD‐L1, CD274) – associations with gene expression, mutational load, and survival

In conclusion, PD‐L1 CNAs, in particular PD‐L1 copy number gains, represent frequent genetic alterations across many cancers, which influence PD‐L1 expression levels, are associated with higher mutational loads, and may be exploitable as predictive biomarker for immunotherapy regimens. © 2016 Wiley Periodicals, Inc.

Source: Genes, Chromosomes and Cancer - May 29, 2016 Category: Cancer & Oncology Authors: Jan Budczies, Michael Bockmayr, Carsten Denkert, Frederick Klauschen, Stefan Gröschel, Silvia Darb‐Esfahani, Nicole Pfarr, Jonas Leichsenring, Maristela L. Onozato, Jochen K. Lennerz, Manfred Dietel, Stefan Fröhling, Peter Schirmacher, A. John Iafrate Tags: Research Article Source Type: research