Sulforaphane effects on post-infarction cardiac remodeling in rats: modulation of redox-sensitive pro-survival and pro-apoptotic proteins

This study investigated whether sulforaphane (SFN), a compound found in cruciferous vegetables, could attenuate the progression of post-myocardial infarction (MI) cardiac remodeling. Male Wistar rats (350 g) were allocated to four groups: SHAM (n=8), SHAM+SFN (n=7), MI (n=8), and MI+SFN (n=5). On the third day after surgery, cardiac function was assessed and SFN treatment (5 mg/Kg/day) was started. At the end of 25 days of treatment, cardiac function was assessed and heart was collected to measure collagen content, oxidative stress and protein kinase.

http://www.jnutbio.com/article/S0955-2863(16)30098-5/abstract?rss=yes

Source: The Journal of Nutritional Biochemistry - May 26, 2016 Category: Biochemistry Authors: Rafael Oliveira Fernandes, Alexandre Luz De Castro, Jéssica Hellen Poletto Bonetto, Vanessa Duarte Ortiz, Dalvana Daneliza Müller, Cristina Campos Carraro, Sílvia Barbosa, Laura Tartari Neves, Léder Leal Xavier, Paulo Cavalheiro Schenkel, Pawan Singal Source Type: research