Validation of Models Used to Inform Colorectal Cancer Screening Guidelines: Accuracy and Implications

Conclusion. Model accuracy can only be established through external validation. Analyses such as these are therefore essential for any decision model. Results supported the assumptions that the average time from adenoma initiation to development of preclinical cancer is long (up to 25 years), and mean sojourn time is close to 4 years, suggesting the window for early detection and intervention by screening is relatively long. Variation in dwell time remains uncertain and could have important clinical and policy implications.

Source: Medical Decision Making - May 24, 2016 Category: Health Management Authors: Rutter, C. M., Knudsen, A. B., Marsh, T. L., Doria-Rose, V. P., Johnson, E., Pabiniak, C., Kuntz, K. M., van Ballegooijen, M., Zauber, A. G., Lansdorp-Vogelaar, I. Tags: Original Articles Source Type: research