Combination of opioid medications shows promise in treatment‐resistant depression

A new study has found that a combination of the opioid partial agonist buprenorphine and the opioid antagonist samidorphan improved depression outcome measures in adults who had not responded adequately to one or two courses of antidepressant treatment. Patients receiving a dose of 2 mg of each drug showed greater improvement than patients receiving a higher dose of 8 mg of each drug. Results were published online Feb. 12 in the American Journal of Psychiatry.

Source: The Brown University Psychopharmacology Update - May 26, 2016 Category: Psychiatry Tags: Adjunctive Therapy Source Type: research