Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour

Conclusions
As IGF-1 and IGF-1R immunoreactivity was detected in the majority of sporadic schwannoma specimens regardless of their anatomical location, these findings suggest that an IGF-1/IGF-1R loop could play a role in the tumorigenesis and progression of schwannomas via an autocrine–paracrine mechanism.

Source: Journal of International Medical Research - May 24, 2016 Category: Research Authors: Matsubara, F., Katabami, T., Asai, S., Ariizumi, Y., Maeda, I., Takagi, M., Keely, M. M., Ono, K., Maekawa, T., Nakamura, Y., Tanaka, Y., Sasano, H. Tags: Clinical Reports Source Type: research