Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape

Nature Reviews Cancer 16, 359 (2016). doi:10.1038/nrc.2016.41 Authors: Fan Liu, Lan Wang, Fabiana Perna & Stephen D. Nimer Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise from mutations
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research