Tumour microenvironment: Genotype puts tension on a tumour

Nature Reviews Cancer 16, 341 (2016). doi:10.1038/nrc.2016.57 Author: Anna Dart SMAD4-mutant pancreatic ductal adenocarcinomas (PDACs) with impaired transforming growth factor-β (TGFβ) signalling initiate a signal transducer and activator of transcription 3 (STAT3)-dependent signalling pathway that leads to increased stromal stiffening and aggressive disease.
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research