Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair

In this study, the effects of matrix metalloproteinase inhibition on the performance of platelet gel spiked with cardiac stem cells (cell-gel) for heart regeneration are explored. The results demonstrate that matrix metalloproteinases are required for cell-gel to exert its benefits in cardiac repair. Inhibition of matrix metalloproteinases reduces cell engraftment, host angiogenesis, and recruitment of endogenous cardiovascular cells in rats with heart attack.

Source: Stem Cells Translational Medicine - May 23, 2016 Category: Stem Cells Authors: Shen, D., Tang, J., Hensley, M. T., Li, T., Caranasos, T. G., Zhang, T., Zhang, J., Cheng, K. Tags: Tissue Engineering and Regenerative Medicine, Cardiac Stem Cells Source Type: research